Publications
2025
Metabolic profiling of meningioma reveals novel subgroup-specific biologic insights and outcome dependencies.
Landry AP, Wang JZ, Yefet LS, Liu J, Patil V, Zhang WJ, Sosa J, Ellenbogen Y, Gui C, Ajisebutu A, Aldape K, Gao A, Kislinger T, Chen EX, Nassiri F, Zadeh G.
Neuro Oncol. 2025 Jan 24:noae281. doi: 10.1093/neuonc/noae281. Online ahead of print.Multi-Omics Study Reveals Nc886/vtRNA2-1 as a Positive Regulator of Prostate Cancer Cell Immunity.
Oliveira-Rizzo C, Colantuono CL, Fernández-Alvarez AJ, Boccaccio GL, Garat B, Sotelo-Silveira JR, Khan S, Ignatchenko V, Lee YS, Kislinger T, Liu SK, Fort RS, Duhagon MA.
J Proteome Res. 2025 Feb 7;24(2):433-448. doi: 10.1021/acs.jproteome.4c00521. Epub 2024 Dec 26.Unveiling the structural proteome of an Alzheimer's disease rat brain model.
Samani EK, Hasan SMN, Waas M, Keszei AFA, Xu X, Heydari M, Hill ME, McLaurin J, Kislinger T, Mazhab-Jafari MT.
Structure. 2025 Jan 2;33(1):51-61.e3. doi: 10.1016/j.str.2024.11.004. Epub 2024 Nov 29.Prediction of brain metastasis development with DNA methylation signatures.
Zuccato JA, Mamatjan Y, Nassiri F, Ajisebutu A, Liu JC, Muazzam A, Singh O, Zhang W, Voisin M, Mirhadi S, Suppiah S, Wybenga-Groot L, Tajik A, Simpson C, Saarela O, Tsao MS, Kislinger T, Aldape KD, Moran MF, Patil V, Zadeh G.
Nat Med. 2025 Jan;31(1):116-125. doi: 10.1038/s41591-024-03286-y. Epub 2024 Oct 8.
Molecular correlates for HPV-negative head and neck cancer engraftment prognosticate patient outcomes.
Waas M, Karamboulas C, Wu BZ, Khan S, Poon S, Meens J, Govindarajan M, Khoo A, Mejia-Guerrero S, Ha A, Liu LY, Nixon KCJ, Walton J, Bratman SV, Huang SH, Goldstein D, Gaiti F, Ailles L, Kislinger T.
Nat Commun. 2024 Dec 30;15(1):10869. doi: 10.1038/s41467-024-55203-z.Accelerated growth and local progression of radiorecurrent prostate cancer in an orthotopic bioluminescent mouse model.
Frame G, Huang X, Haas R, Khan KA, Leong HS, Kislinger T, Boutros PC, Downes M, Liu SK.
Sci Rep. 2024 Dec 28;14(1):31205. doi: 10.1038/s41598-024-82546-w.Protocol for generating high-fidelity proteomic profiles using DROPPS.
Waas M, Govindarajan M, Khoo A, Zuo C, Aastha A, He J, Woolman M, Ha A, Lin B, Kislinger T.
STAR Protoc. 2024 Dec 20;5(4):103397. doi: 10.1016/j.xpro.2024.103397. Epub 2024 Oct 18.Cysteamine dioxygenase (ADO) governs cancer cell mitochondrial redox homeostasis through proline metabolism.
Lee SCS, Pyo AHA, Mohammadi H, Zhang J, Dvorkin-Gheva A, Malbeteau L, Chung S, Khan S, Ciudad MT, Rondeau V, Cairns RA, Kislinger T, McGaha TL, Wouters BG, Reisz JA, Culp-Hill R, D'Alessandro A, Jones CL, Koritzinsky M.
Sci Adv. 2024 Oct 4;10(40):eadq0355. doi: 10.1126/sciadv.adq0355. Epub 2024 Oct 2.Targeting PLOD2 suppresses invasion and metastatic potential in radiorecurrent prostate cancer.
Frame G, Leong H, Haas R, Huang X, Wright J, Emmenegger U, Downes M, Boutros PC, Kislinger T, Liu SK.
BJC Rep. 2024;2(1):60. doi: 10.1038/s44276-024-00085-3. Epub 2024 Aug 21.The Proteogenomics of Prostate Cancer Radioresistance.
Haas R, Frame G, Khan S, Neilsen BK, Hong BH, Yeo CPX, Yamaguchi TN, Ong EHW, Zhao W, Carlin B, Yeo ELL, Tan KM, Bugh YZ, Zhu C, Hugh-White R, Livingstone J, Poon DJJ, Chu PL, Patel Y, Tao S, Ignatchenko V, Kurganovs NJ, Higgins GS, Downes MR, Loblaw A, Vesprini D, Kishan AU, Chua MLK, Kislinger T, Boutros PC, Liu SK.
Cancer Res Commun. 2024 Sep 1;4(9):2463-2479. doi: 10.1158/2767-9764.CRC-24-0292.Establishing the utility of multi-platform liquid biopsy by integrating the CSF methylome and proteome in CNS tumours.
Landry AP, Zuccato JA, Patil V, Voisin MR, Wang JZ, Ellenbogen Y, Gui C, Ajisebutu A, Kislinger T, Nassiri F, Zadeh G.
J Neurooncol. 2024 Sep;169(2):233-239. doi: 10.1007/s11060-024-04695-2. Epub 2024 Aug 5.Targeting axonal guidance dependencies in glioblastoma with ROBO1 CAR T cells.
Chokshi CR, Shaikh MV, Brakel B, Rossotti MA, Tieu D, Maich W, Anand A, Chafe SC, Zhai K, Suk Y, Kieliszek AM, Miletic P, Mikolajewicz N, Chen D, McNicol JD, Chan K, Tong AHY, Kuhlmann L, Liu L, Alizada Z, Mobilio D, Tatari N, Savage N, Aghaei N, Grewal S, Puri A, Subapanditha M, McKenna D, Ignatchenko V, Salamoun JM, Kwiecien JM, Wipf P, Sharlow ER, Provias JP, Lu JQ, Lazo JS, Kislinger T, Lu Y, Brown KR, Venugopal C, Henry KA, Moffat J, Singh SK.
Nat Med. 2024 Oct;30(10):2936-2946. doi: 10.1038/s41591-024-03138-9. Epub 2024 Aug 2.Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes.
Khoo A, Govindarajan M, Qiu Z, Liu LY, Ignatchenko V, Waas M, Macklin A, Keszei A, Neu S, Main BP, Yang L, Lance RS, Downes MR, Semmes OJ, Vesprini D, Liu SK, Nyalwidhe JO, Boutros PC, Kislinger T.
Nat Commun. 2024 Jun 13;15(1):5069. doi: 10.1038/s41467-024-49424-5.Systematic Review of Cerebrospinal Fluid Biomarker Discovery in Neuro-Oncology: A Roadmap to Standardization and Clinical Application.
Mikolajewicz N, Yee PP, Bhanja D, Trifoi M, Miller AM, Metellus P, Bagley SJ, Balaj L, de Macedo Filho LJM, Zacharia BE, Aregawi D, Glantz M, Weller M, Ahluwalia MS, Kislinger T, Mansouri A.
J Clin Oncol. 2024 Jun 1;42(16):1961-1974. doi: 10.1200/JCO.23.01621. Epub 2024 Apr 12.moPepGen: Rapid and Comprehensive Identification of Non-canonical Peptides.
Zhu C, Liu LY, Ha A, Yamaguchi TN, Zhu H, Hugh-White R, Livingstone J, Patel Y, Kislinger T, Boutros PC.
bioRxiv [Preprint]. 2024 Nov 5:2024.03.28.587261. doi: 10.1101/2024.03.28.587261.Comprehensive Prostate Fluid-Based Spectral Libraries for Enhanced Protein Detection in Urine.
Ha A, Khoo A, Ignatchenko V, Khan S, Waas M, Vesprini D, Liu SK, Nyalwidhe JO, Semmes OJ, Boutros PC, Kislinger T.
J Proteome Res. 2024 May 3;23(5):1768-1778. doi: 10.1021/acs.jproteome.4c00009. Epub 2024 Apr 5.Droplet-based proteomics reveals CD36 as a marker for progenitors in mammary basal epithelium.
Waas M, Khoo A, Tharmapalan P, McCloskey CW, Govindarajan M, Zhang B, Khan S, Waterhouse PD, Khokha R, Kislinger T.
Cell Rep Methods. 2024 Apr 22;4(4):100741. doi: 10.1016/j.crmeth.2024.100741. Epub 2024 Apr 2.Organelle resolved proteomics uncovers PLA2R1 as a novel cell surface marker required for chordoma growth.
Khan S, Zuccato JA, Ignatchenko V, Singh O, Govindarajan M, Waas M, Mejia-Guerrero S, Gao A, Zadeh G, Kislinger T.
Acta Neuropathol Commun. 2024 Mar 7;12(1):39. doi: 10.1186/s40478-024-01751-w.The proteomic landscape of genotoxic stress-induced micronuclei.
MacDonald KM, Khan S, Lin B, Hurren R, Schimmer AD, Kislinger T, Harding SM.
Mol Cell. 2024 Feb 22:S1097-2765(24)00097-2. doi: 10.1016/j.molcel.2024.02.001. Online ahead of print.Recent developments in mass-spectrometry-based targeted proteomics of clinical cancer biomarkers.
Wenk D, Zuo C, Kislinger T, Sepiashvili L.
Clin Proteomics. 2024 Jan 30;21(1):6. doi: 10.1186/s12014-024-09452-1.Targeted Mass Spectrometry of Longitudinal Patient Sera Reveals LTBP1 as a Potential Surveillance Biomarker for High-Grade Serous Ovarian Carcinoma
Wenk D, Khan S, Ignatchenko V, May T, Bernardini MQ, Kislinger T.
J Proteome Res. 2024 Feb 2;23(2):749-759. doi: 10.1021/acs.jproteome.3c00629. Epub 2024 Jan 24.
Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages.
Kim H, Aliar K, Tharmapalan P, McCloskey CW, Kuttanamkuzhi A, Grünwald BT, Palomero L, Mahendralingam MJ, Waas M, Mer AS, Elliott MJ, Zhang B, Al-Zahrani KN, Langille ER, Parsons M, Narala S, Hofer S, Waterhouse PD, Hakem R, Haibe-Kains B, Kislinger T, Schramek D, Cescon DW, Pujana MA, Berman HK, Khokha R.
Cell Rep. 2023 Nov 28;42(11):113382. doi: 10.1016/j.celrep.2023.113382. Epub 2023 Oct 25.Correction to: Dynamic profiling of medulloblastoma surfaceome.
Bakhshinyan D, Suk Y, Kuhlmann L, Adile AA, Ignatchenko V, Custers S, Gwynne WD, Macklin A, Venugopal C, Kislinger T, Singh SK.
Acta Neuropathol Commun. 2023 Oct 23;11(1):169. doi: 10.1186/s40478-023-01666-y.Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages.
Kim H, Aliar K, Tharmapalan P, McCloskey CW, Kuttanamkuzhi A, Grünwald BT, Palomero L, Mahendralingam MJ, Waas M, Mer AS, Elliott MJ, Zhang B, Al-Zahrani KN, Langille ER, Parsons M, Narala S, Hofer S, Waterhouse PD, Hakem R, Haibe-Kains B, Kislinger T, Schramek D, Cescon DW, Pujana MA, Berman HK, Khokha R.
Cell Rep. 2023 Oct 31;42(10):113256. doi: 10.1016/j.celrep.2023.113256. Epub 2023 Oct 16.Prostate Cancer Reshapes the Secreted and Extracellular Vesicle Urinary Proteomes.
Khoo A, Govindarajan M, Qiu Z, Liu LY, Ignatchenko V, Waas M, Macklin A, Keszei A, Main BP, Yang L, Lance RS, Downes MR, Semmes OJ, Vesprini D, Liu SK, Nyalwidhe JO, Boutros PC, Kislinger T.
bioRxiv. 2023 Jul 25:2023.07.23.550214. doi: 10.1101/2023.07.23.550214. Preprint.Dynamic profiling of medulloblastoma surfaceome.
Bakhshinyan D, Suk Y, Kuhlmann L, Adile AA, Ignatchenko V, Custers S, Gwynne WD, Macklin A, Venugopal C, Kislinger T, Singh SK.
Acta Neuropathol Commun. 2023 Jul 10;11(1):111. doi: 10.1186/s40478-023-01609-7.Transcriptomic classes of BCR-ABL1 lymphoblastic leukemia.
Kim JC, Chan-Seng-Yue M, Ge S, Zeng AGX, Ng K, Gan OI, Garcia-Prat L, Flores-Figueroa E, Woo T, Zhang AXW, Arruda A, Chithambaram S, Dobson SM, Khoo A, Khan S, Ibrahimova N, George A, Tierens A, Hitzler J, Kislinger T, Dick JE, McPherson JD, Minden MD, Notta F.
Nat Genet. 2023 Jul;55(7):1186-1197. doi: 10.1038/s41588-023-01429-4. Epub 2023 Jun 19.Phosphoproteomic Analysis of Dopamine D2 Receptor Signaling Reveals Interplay of G Protein- and β-Arrestin-Mediated Effects
Wenk D, Khan S, Ignatchenko V, Hübner H, Gmeiner P, Weikert D, Pischetsrieder M, Kislinger T.
J Proteome Res. 2023 Jan 6;22(1):259-271. doi: 10.1021/acs.jproteome.2c00707. Epub 2022 Dec 12.Mitochondrial aconitase ACO2 links iron homeostasis with tumorigenicity in non-small cell lung cancer.
Mirhadi S, Zhang W, Pham NA, Karimzadeh F, Pintilie M, Tong J, Taylor P, Krieger J, Pitcher B, Sykes J, Wybenga-Groot L, Fladd C, Xu J, Wang T, Cabanero M, Li M, Weiss J, Sakashita S, Zaslaver O, Yu M, Caudy AA, St-Pierre J, Hawkins C, Kislinger T, Liu G, Shepherd FA, Tsao MS, Moran MF.
Mol Cancer Res. 2023 Jan 3;21(1):36-50. doi: 10.1158/1541-7786.MCR-22-0163.
Proteomics of High-Grade Serous Ovarian Cancer Models Identifies Cancer-Associated Fibroblast Markers Associated with Clinical Outcomes
Govindarajan M, Ignatchenko V, Ailles L, Kislinger T.
Biomolecules. 2022 Dec 30;13(1):75. doi: 10.3390/biom13010075.Leveraging the CSF proteome toward minimally-invasive diagnostics surveillance of brain malignancies.
Mikolajewicz N, Khan S, Trifoi M, Skakdoub A, Ignatchenko V, Mansouri S, Zuccatto J, Zacharia BE, Glantz M, Zadeh G, Moffat J, Kislinger T, Mansouri A.
Neurooncol Adv. 2022 Oct 7;4(1):vdac161. doi: 10.1093/noajnl/vdac161. eCollection 2022 Jan-Dec.Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts.
Teng ACT, Gu L, Di Paola M, Lakin R, Williams ZJ, Au A, Chen W, Callaghan NI, Zadeh FH, Zhou YQ, Fatah M, Chatterjee D, Jourdan LJ, Liu J, Simmons CA, Kislinger T, Yip CM, Backx PH, Gourdie RG, Hamilton RM, Gramolini AO.
Nat Commun. 2022 Oct 18;13(1):6166. doi: 10.1038/s41467-022-33303-y.The proteomic landscape of glioblastoma recurrence reveals novel and targetable immunoregulatory drivers.
Tatari N, Khan S, Livingstone J, Zhai K, Mckenna D, Ignatchenko V, Chokshi C, Gwynne WD, Singh M, Revill S, Mikolajewicz N, Zhu C, Chan J, Hawkins C, Lu JQ, Provias JP, Ask K, Morrissy S, Brown S, Weiss T, Weller M, Han H, Greenspoon JN, Moffat J, Venugopal C, Boutros PC, Singh SK, Kislinger T.
Acta Neuropathol. 2022 Dec;144(6):1127-1142. doi: 10.1007/s00401-022-02506-4. Epub 2022 Sep 30.Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastoma.
Qazi MA, Salim SK, Brown KR, Mikolajewicz N, Savage N, Han H, Subapanditha MK, Bakhshinyan D, Nixon A, Vora P, Desmond K, Chokshi C, Singh M, Khoo A, Macklin A, Khan S, Tatari N, Winegarden N, Richards L, Pugh T, Bock N, Mansouri A, Venugopal C, Kislinger T, Goyal S, Moffat J, Singh SK.
Cell Rep. 2022 Sep 27;40(13):111420. doi: 10.1016/j.celrep.2022.111420.Glycoproteomics Identifies Plexin-B3 as a Targetable Cell Surface Protein Required for the Growth and Invasion of Triple-Negative Breast Cancer Cells.
Kuhlmann L, Govindarajan M, Mejia-Guerrero S, Ignatchenko V, Liu LY, Grünwald BT, Cruickshank J, Berman H, Khokha R, Kislinger T.
J Proteome Res. 2022 Sep 2;21(9):2224-2236. doi: 10.1021/acs.jproteome.2c00332. Epub 2022 Aug 18.Prostate cancer multiparametric magnetic resonance imaging visibility is a tumor-intrinsic phenomena.
Khoo A, Liu LY, Sadun TY, Salmasi A, Pooli A, Felker E, Houlahan KE, Ignatchenko V, Raman SS, Sisk AE Jr, Reiter RE, Boutros PC, Kislinger T.
J Hematol Oncol. 2022 May 3;15(1):48. doi: 10.1186/s13045-022-01268-6.DNA Methylation based prognostic subtypes of chordoma tumors in tissue and plasma.
Zuccato JA, Patil V, Mansouri S, Liu JC, Nassiri F, Mamatjan Y, Chakravarthy A, Karimi S, Almeida JP, Bernat AL, Hasen M, Singh O, Khan S, Kislinger T, Sinha N, Froelich S, Adle-Biassette H, Aldape KD, De Carvalho DD, Zadeh G.
Neuro Oncol. 2022 Mar 12;24(3):442-454. doi: 10.1093/neuonc/noab235.Optimization of small extracellular vesicle isolation from expressed prostatic secretions in urine for in-depth proteomic analysis.
Correll VL, Otto JJ, Risi CM, Main BP, Boutros PC, Kislinger T, Galkin VE, Nyalwidhe JO, Semmes OJ, Yang L.
J Extracell Vesicles. 2022 Feb;11(2):e12184. doi: 10.1002/jev2.12184.CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment.
Seyfrid M, Maich WT, Shaikh VM, Tatari N, Upreti D, Piyasena D, Subapanditha M, Savage N, McKenna D, Mikolajewicz N, Han H, Chokshi C, Kuhlmann L, Khoo A, Salim SK, Archibong-Bassey B, Gwynne W, Brown K, Murtaza N, Bakhshinyan D, Vora P, Venugopal C, Moffat J, Kislinger T, Singh S.
J Immunother Cancer. 2022 Jan;10(1):e003289. doi: 10.1136/jitc-2021-003289.
Spatially confined sub-tumor microenvironments in pancreatic cancer.
Grünwald BT, Devisme A, Andrieux G, Vyas F, Aliar K, McCloskey CW, Macklin A, Jang GH, Denroche R, Romero JM, Bavi P, Bronsert P, Notta F, O'Kane G, Wilson J, Knox J, Tamblyn L, Udaskin M, Radulovich N, Fischer SE, Boerries M, Gallinger S, Kislinger T, Khokha R.
Cell. 2021 Oct 28;184(22):5577-5592.e18. doi: 10.1016/j.cell.2021.09.022. Epub 2021 Oct 12.Proteomic discovery of non-invasive biomarkers of localized prostate cancer using mass spectrometry.
Khoo A, Liu LY, Nyalwidhe JO, Semmes OJ, Vesprini D, Downes MR, Boutros PC, Liu SK, Kislinger T.
Nat Rev Urol. 2021 Aug 27. doi: 10.1038/s41585-021-00500-1. Online ahead of print.A clinically applicable integrative molecular classification of meningiomas.
Nassiri F, Liu J, Patil V, Mamatjan Y, Wang JZ, Hugh-White R, Macklin AM, Khan S, Singh O, Karimi S, Corona RI, Liu LY, Chen CY, Chakravarthy A, Wei Q, Mehani B, Suppiah S, Gao A, Workewych AM, Tabatabai G, Boutros PC, Bader GD, de Carvalho DD, Kislinger T, Aldape K, Zadeh G.
Nature. 2021 Sep;597(7874):119-125. doi: 10.1038/s41586-021-03850-3. Epub 2021 Aug 25.A proteomic investigation of isogenic radiation resistant prostate cancer cell lines.
Kurganovs N, Wang H, Huang X, Ignatchenko V, Macklin A, Khan S, Downes MR, Boutros PC, Liu SK, Kislinger T.
Proteomics Clin Appl. 2021 Jun 21:e2100037. doi: 10.1002/prca.202100037. Online ahead of print.Mammary epithelial cells have lineage-rooted metabolic identities.
Mahendralingam MJ, Kim H, McCloskey CW, Aliar K, Casey AE, Tharmapalan P, Pellacani D, Ignatchenko V, Garcia-Valero M, Palomero L, Sinha A, Cruickshank J, Shetty R, Vellanki RN, Koritzinsky M, Stambolic V, Alam M, Schimmer AD, Berman HK, Eaves CJ, Pujana MA, Kislinger T, Khokha R.
Nat Metab. 2021 May;3(5):665-681. doi: 10.1038/s42255-021-00388-6. Epub 2021 May 20.Rat Sciatic Nerve Axoplasm Proteome Is Enriched with Ribosomal Proteins during Regeneration Processes.
Di Paolo A, Farias J, Garat J, Macklin A, Ignatchenko V, Kislinger T, Sotelo Silveira J.
J Proteome Res. 2021 Apr 1. doi: 10.1021/ acs.jproteome.0c00980. Online ahead of print.Functionally selective activation of the dopamine receptor D2 is mirrored by the protein expression profiles.
Wenk D, Ignatchenko V, Macklin A, Hübner H, Gmeiner P, Weikert D, Pischetsrieder M, Kislinger T.
Sci Rep. 2021 Feb 10;11(1):3501. doi: 10.1038/s41598-021-83038-x.
Quantifying the influence of mutation detection on tumour subclonal reconstruction.
Liu LY, Bhandari V, Salcedo A, Espiritu SMG, Morris QD, Kislinger T, Boutros PC.
Nat Commun. 2020 Dec 7;11(1):6247. doi: 10.1038/s41467-020-20055-w.Bioinformatic analysis of membrane and associated proteins in murine cardiomyocytes and human myocardium.
Lee SH, Hadipour-Lakmehsari S, Kim DH, Di Paola M, Kuzmanov U, Shah S, Lee JJ, Kislinger T, Sharma P, Oudit GY, Gramolini AO.
Sci Data. 2020 Dec 1;7(1):425. doi: 10.1038/s41597-020-00762-1.Standardization and harmonization of distributed multi-center proteotype analysis supporting precision medicine studies.
Xuan Y, Bateman NW, Gallien S, Goetze S, Zhou Y, Navarro P, Hu M, Parikh N, Hood BL, Conrads KA, Loosse C, Kitata RB, Piersma SR, Chiasserini D, Zhu H, Hou G, Tahir M, Macklin A, Khoo A, Sun X, Crossett B, Sickmann A, Chen YJ, Jimenez CR, Zhou H, Liu S, Larsen MR, Kislinger T, Chen Z, Parker BL, Cordwell SJ, Wollscheid B, Conrads TP.
Nat Commun. 2020 Oct 16;11(1):5248. doi: 10.1038/s41467-020-18904-9.High-throughput approaches for precision medicine in high-grade serous ovarian cancer.
Govindarajan M, Wohlmuth C, Waas M, Bernardini MQ, Kislinger T.
J Hematol Oncol. 2020 Oct 9;13(1):134. doi: 10.1186/s13045-020-00971-6.PDCD4 regulates axonal growth by translational repression of neurite growth-related genes and is modulated during nerve injury responses.
Di Paolo A, Eastman G, Mesquita-Ribeiro R, Farias J, Macklin A, Kislinger T, Colburn N, Munroe D, Sotelo Sosa JR, Dajas-Bailador F, Sotelo-Silveira JR.
RNA. 2020 Nov;26(11):1637-1653. doi: 10.1261/rna.075424.120. Epub 2020 Aug 3.Addressing Cellular Heterogeneity in Cancer through Precision Proteomics.
Waas M, Kislinger T.
J Proteome Res. 2020 Aug 10. doi: 10.1021/acs.jproteome.0c00338.Targeted Mass Spectrometry of a Clinically Relevant PSA Variant from Post-DRE Urines for Quantitation and Genotype Determination.
Otto JJ, Correll VL, Engstroem HA, Hitefield NL, Main BP, Albracht B, Johnson-Pais T, Yang LF, Liss M, Boutros PC, Kislinger T, Leach RJ, Semmes OJ, Nyalwidhe JO.
Proteomics Clin Appl. 2020 Nov;14(6):e2000012. doi: 10.1002/prca.202000012. Epub 2020 Jul 9.Recent advances in mass spectrometry based clinical proteomics: applications to cancer research.
Macklin A, Khan S, Kislinger T.
Clin Proteomics. 2020 May 24;17:17. doi: 10.1186/s12014-020-09283-w. eCollection 2020.REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects.
Lee SH, Hadipour-Lakmehsari S, Murthy HR, Gibb N, Miyake T, Teng ACT, Cosme J, Yu JC, Moon M, Lim S, Wong V, Liu P, Billia F, Fernandez-Gonzalez R, Stagljar I, Sharma P, Kislinger T, Scott IC, Gramolini AO.
Nat Commun. 2020 Feb 19;11(1):965. doi: 10.1038/s41467-019-14143-9.
Genome-wide germline correlates of the epigenetic landscape of prostate cancer.
Houlahan KE, Shiah YJ, Gusev A, Yuan J, Ahmed M, Shetty A, Ramanand SG, Yao CQ, Bell C, O'Connor E, Huang V, Fraser M, Heisler LE, Livingstone J, Yamaguchi TN, Rouette A, Foucal A, Espiritu SMG, Sinha A, Sam M, Timms L, Johns J, Wong A, Murison A, Orain M, Picard V, Hovington H, Bergeron A, Lacombe L, Lupien M, Fradet Y, Têtu B, McPherson JD, Pasaniuc B, Kislinger T, Chua MLK, Pomerantz MM, van der Kwast T, Freedman ML, Mani RS, He HH, Bristow RG, Boutros PC.
Nat Med. 2019 Oct;25(10):1615-1626. doi: 10.1038/s41591-019-0579-z. Epub 2019 Oct 7.Metalloprotease inhibitor TIMP proteins control FGF-2 bioavailability and regulate skeletal growth.
Saw S, Aiken A, Fang H, McKee TD, Bregant S, Sanchez O, Chen Y, Weiss A, Dickson BC, Czarny B, Sinha A, Fosang A, Dive V, Waterhouse PD, Kislinger T, Khokha R.
J Cell Biol. 2019 Sep 2;218(9):3134-3152. doi: 10.1083/jcb.201906059. Epub 2019 Aug 1.N-Glycoproteomics of Patient-Derived Xenografts: A Strategy to Discover Tumor-Associated Proteins in High-Grade Serous Ovarian Cancer.
Sinha A, Hussain A, Ignatchenko V, Ignatchenko A, Tang KH, Ho VWH, Neel BG, Clarke B, Bernardini MQ, Ailles L, Kislinger T.
Cell Syst. 2019 Apr 24;8(4):345-351.e4. doi: 10.1016/j.cels.2019.03.011. Epub 2019 Apr 10.The Proteogenomic Landscape of Curable Prostate Cancer.
Sinha A, Huang V, Livingstone J, Wang J, Fox NS, Kurganovs N, Ignatchenko V, Fritsch K, Donmez N, Heisler LE, Shiah YJ, Yao CQ, Alfaro JA, Volik S, Lapuk A, Fraser M, Kron K, Murison A, Lupien M, Sahinalp C, Collins CC, Tetu B, Masoomian M, Berman DM, van der Kwast T, Bristow RG, Kislinger T, Boutros PC.
Cancer Cell. 2019 Mar 18;35(3):414-427.e6. doi: 10.1016/j.ccell.2019.02.005.
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines.
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J Extracell Vesicles. 2018 Nov 23;7(1):1535750. doi: 10.1080/20013078.2018.1535750. eCollection 2018.Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo.
Sonzogni O, Haynes J, Seifried LA, Kamel YM, Huang K, BeGora MD, Yeung FA, Robert-Tissot C, Heng YJ, Yuan X, Wulf GM, Kron KJ, Wagenblast E, Lupien M, Kislinger T, Hannon GJ, Muthuswamy SK.
PLoS Biol. 2018 Jun 20;16(6):e2004049. doi: 10.1371/journal.pbio.2004049. eCollection 2018 Jun.Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities.
Casey AE, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, Cruickshank J, Shehata M, Drysdale E, Fang H, Kim H, Isserlin R, Bailey S, Medina T, Deblois G, Shiah YJ, Barsyte-Lovejoy D, Hofer S, Bader G, Lupien M, Arrowsmith C, Knapp S, De Carvalho D, Berman H, Boutros PC, Kislinger T, Khokha R.
J Cell Biol. 2018 Aug 6;217(8):2951-2974. doi: 10.1083/jcb.201804042. Epub 2018 Jun 19.Proteomic Analysis of Cancer-Associated Fibroblasts Reveals a Paracrine Role for MFAP5 in Human Oral Tongue Squamous Cell Carcinoma.
Principe S, Mejia-Guerrero S, Ignatchenko V, Sinha A, Ignatchenko A, Shi W, Pereira K, Su S, Huang SH, O'Sullivan B, Xu W, Goldstein DP, Weinreb I, Ailles L, Liu FF, Kislinger T.
J Proteome Res. 2018 Jun 1;17(6):2045-2059. doi: 10.1021/acs.jproteome.7b00925. Epub 2018 May 2.Cell-surface proteomics for the identification of novel therapeutic targets in cancer.
Kuhlmann L, Cummins E, Samudio I, Kislinger T.
Expert Rev Proteomics. 2018 Mar;15(3):259-275. doi: 10.1080/14789450.2018.1429924. Epub 2018 Jan 23.Proteomic Profiling of Secreted Proteins, Exosomes, and Microvesicles in Cell Culture Conditioned Media.
Sinha A, Principe S, Alfaro J, Ignatchenko A, Ignatchenko V, Kislinger T.
Methods Mol Biol. 2018;1722:91-102. doi: 10.1007/978-1-4939-7553-2_6.Divergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization.
Garnier D, Meehan B, Kislinger T, Daniel P, Sinha A, Abdulkarim B, Nakano I, Rak J.
Neuro Oncol. 2018 Jan 22;20(2):236-248. doi: 10.1093/neuonc/nox142.
Proteomic Response of Human Umbilical Vein Endothelial Cells to Histamine Stimulation.
Emirbayer PE, Sinha A, Ignatchenko V, Hoyer S, Dörrie J, Schaft N, Pischetsrieder M, Kislinger T.
Proteomics. 2017 Nov;17(21). doi: 10.1002/pmic.201700116. Epub 2017 Oct 12.Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors.
Cogger KF, Sinha A, Sarangi F, McGaugh EC, Saunders D, Dorrell C, Mejia-Guerrero S, Aghazadeh Y, Rourke JL, Screaton RA, Grompe M, Streeter PR, Powers AC, Brissova M, Kislinger T, Nostro MC.
Nat Commun. 2017 Aug 24;8(1):331. doi: 10.1038/s41467-017-00561-0.A novel community driven software for functional enrichment analysis of extracellular vesicles data.
Pathan M, Keerthikumar S, Chisanga D, Alessandro R, Ang CS, Askenase P, Batagov AO, Benito-Martin A, Camussi G, Clayton A, Collino F, Di Vizio D, Falcon-Perez JM, Fonseca P, Fonseka P, Fontana S, Gho YS, Hendrix A, Hoen EN, Iraci N, Kastaniegaard K, Kislinger T, Kowal J, Kurochkin IV, Leonardi T, Liang Y, Llorente A, Lunavat TR, Maji S, Monteleone F, Øverbye A, Panaretakis T, Patel T, Peinado H, Pluchino S, Principe S, Ronquist G, Royo F, Sahoo S, Spinelli C, Stensballe A, Théry C, van Herwijnen MJC, Wauben M, Welton JL, Zhao K, Mathivanan S.
J Extracell Vesicles. 2017 May 26;6(1):1321455. doi: 10.1080/20013078.2017.1321455. eCollection 2017.Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines.
Alfaro JA, Ignatchenko A, Ignatchenko V, Sinha A, Boutros PC, Kislinger T.
Genome Med. 2017 Jul 18;9(1):62. doi: 10.1186/s13073-017-0454-9.Quantitative proteomics of intestinal mucosa from male mice lacking intestinal epithelial insulin receptors.
Jensen SR, Schoof EM, Wheeler SE, Hvid H, Ahnfelt-Rønne J, Hansen BF, Nishimura E, Olsen GS, Kislinger T, Brubaker PL.
Endocrinology. 2017 Jun 7. doi: 10.1210/en.2017-00194. [Epub ahead of print]HLA-DP84Gly constitutively presents endogenous peptides generated by the class I antigen processing pathway.
Yamashita Y, Anczurowski M, Nakatsugawa M, Tanaka M, Kagoya Y, Sinha A, Chamoto K, Ochi T, Guo T, Saso K, Butler MO, Minden MD, Kislinger T, Hirano N.
Nat Commun. 2017 May 10;8:15244. doi: 10.1038/ncomms15244.Characterization of Protein Content Present in Exosomes Isolated from Conditioned Media and Urine.
Sinha A, Alfaro J, Kislinger T.
Curr Protoc Protein Sci. 2017 Feb 2;87:24.9.1-24.9.12. doi: 10.1002/cpps.23.Molecular heterogeneity of non-small cell lung carcinoma patient-derived xenografts closely reflect their primary tumors.
Wang D, Pham NA, Tong J, Sakashita S, Allo G, Kim L, Yanagawa N, Raghavan V, Wei Y, To C, Trinh QM, Starmans MH, Chan-Seng-Yue MA, Chadwick D, Li L, Zhu CQ, Liu N, Li M, Lee S, Ignatchenko V, Strumpf D, Taylor P, Moghal N, Liu G, Boutros PC, Kislinger T, Pintilie M, Jurisica I, Shepherd FA, McPherson JD, Muthuswamy L, Moran MF, Tsao MS.
Int J Cancer. 2017 Feb 1;140(3):662-673. doi: 10.1002/ijc.30472.
Ectopic miR-125a Expression Induces Long-Term Repopulating Stem Cell Capacity in Mouse and Human Hematopoietic Progenitors.
Wojtowicz EE, Lechman ER, Hermans KG, Schoof EM, Wienholds E, Isserlin R, van Veelen PA, Broekhuis MJ, Janssen GM, Trotman-Grant A, Dobson SM, Krivdova G, Elzinga J, Kennedy J, Gan OI, Sinha A, Ignatchenko V, Kislinger T, Dethmers-Ausema B, Weersing E, Alemdehy MF, de Looper HW, Bader GD, Ritsema M, Erkeland SJ, Bystrykh LV, Dick JE, de Haan G.
Cell Stem Cell. 2016 Sep 1;19(3):383-96. doi: 10.1016/j.stem.2016.06.008.Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer.
Kim Y, Jeon J, Mejia S, Yao CQ, Ignatchenko V, Nyalwidhe JO, Gramolini AO, Lance RS, Troyer DA, Drake RR, Boutros PC, Semmes OJ, Kislinger T.
Nat Commun. 2016 Jun 28;7:11906.PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia.
Banh RS, Iorio C, Marcotte R, Xu Y, Cojocari D, Rahman AA, Pawling J, Zhang W, Sinha A, Rose CM, Isasa M, Zhang S, Wu R, Virtanen C, Hitomi T, Habu T, Sidhu SS, Koizumi A, Wilkins SE, Kislinger T, Gygi SP, Schofield CJ, Dennis JW, Wouters BG, Neel BG.
Nat Cell Biol. 2016 Jul;18(7):803-13.Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland.
Baker L, BeGora M, Au Yeung F, Feigin ME, Rosenberg AZ, Lowe SW, Kislinger T, Muthuswamy SK.
J Cell Sci. 2016 Jun 15;129(12):2307-15.Proteotranscriptomic Analysis Reveals Stage Specific Changes in the Molecular Landscape of Clear-Cell Renal Cell Carcinoma.
Neely BA, Wilkins CE, Marlow LA, Malyarenko D, Kim Y, Ignatchenko A, Sasinowska H, Sasinowski M, Nyalwidhe JO, Kislinger T, Copland JA, Drake RR.
PLoS One. 2016 Apr 29;11(4):e0154074.Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker discovery.
Nawaz M, Fatima F, Nazarenko I, Ekstrom K, Murtaza I, Anees M, Sultan A, Neder L, Camussi G, Valadi H, Squire JA, Kislinger T.
Expert Rev Proteomics. 2016 Apr;13(4):395-409.Proteogenomics: Opportunities and Caveats.
Dimitrakopoulos L, Prassas I, Diamandis EP, Nesvizhskii A, Kislinger T, Jaffe J, Drabovich A.
Clin Chem. 2016 Apr;62(4):551-7
Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.
Sharma P, Abbasi C, Lazic S, Teng AC, Wang D, Dubois N, Ignatchenko V, Wong V, Liu J, Araki T, Tiburcy M, Ackerley C, Zimmermann WH, Hamilton R, Sun Y, Liu PP, Keller G, Stagljar I, Scott IC, Kislinger T, Gramolini AO
Nat Commun. 2015 Sep 25;6:8391. doi: 10.1038/ncomms9391.A Genome Scale Screen for Mutants with Delayed Exit from Mitosis: Ire1-Independent Induction of Autophagy Integrates ER Homeostasis into Mitotic Lifespan.
Ghavidel A, Baxi K, Ignatchenko V, Prusinkiewicz M, Arnason TG, Kislinger T, Carvalho CE, Harkness TA.
PLoS Genet. 2015 Aug 6;11(8):e1005429.Semi-supervised Learning Predicts Approximately One Third of the Alternative Splicing Isoforms as Functional Proteins.
Hao Y, Colak R, Teyra J, Corbi-Verge C, Ignatchenko A, Hahne H, Wilhelm M, Kuster B, Braun P, Kaida D, Kislinger T, Kim PM.
Cell Rep. 2015 Jul 14;12(2):183-9.Using proteomics to probe neurons.
Kim Y, Kislinger T.
Elife. 2015 Jul 2;4:e09103.CHCHD2 Is Coamplified with EGFR in NSCLC and Regulates Mitochondrial Function and Cell Migration.
Wei Y1, Vellanki RN, Coyaud E, Ignatchenko V, Li L, Krieger JR, Taylor P, Tong J, Pham NA, Liu G, Raught B, Wouters BG, Kislinger T, Tsao MS, Moran MF.
Mol Cancer Res. 2015 Jul;13(7):1119-29.Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice.
Jackson HW, Waterhouse P, Sinha A, Kislinger T, Berman HK, Khokha R.
Nat Cell Biol. 2015 Mar;17(3):217-27.Novel insights into head and neck cancer using next-generation 'omic' technologies.
Sepiashvili L, Bruce JP, Huang SH, O'Sullivan B, Liu FF, Kislinger T.
Cancer Res. 2015 Feb 1;75(3):480-6.
VennDIS: A JavaFX-based Venn and Euler Diagram Software to Generate Publication Quality Figures.
Ignatchenko V, Ignatchenko A, Sinha A, Boutros PC, Kislinger T.
Proteomics. 2014 Dec 24. doi: 10.1002/pmic.201400320.Integrated Omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact.
Li L, Wei Y, To C, Zhu CQ, Tong J, Pham NA, Taylor P, Ignatchenko V, Ignatchenko A, Zhang W, Wang D, Yanagawa N, Li M, Pintilie M, Liu G, Muthuswamy L, Shepherd FA, Tsao MS, Kislinger T, Moran MF.
Nat Commun. 2014 Nov 28;5:5469. doi: 10.1038/ncomms6469.The emerging role of extracellular vesicles as biomarkers for urogenital cancers.
Nawaz M, Camussi G, Valadi H, Nazarenko I, Ekstrom K, Wang X, Principe S, Shah N, Ashraf NM, Fatima F, Neder L, Kislinger T.
Nat Rev Urol. 2014 Nov 18. doi: 10.1038/nrurol.2014.301. [Epub ahead of print]EVpedia: A Community Web Portal for Extracellular Vesicles Research.
Kim DK, Lee J, Kim SR, Choi DS, Yoon YJ, Kim JH, Go G, Nhung D, Hong K, Jang SC, Kim SH, Park KS, Kim OY, Park HT, Seo JH, Aikawa E, Baj-Krzyworzeka M, van Balkom BW, Belting M, Blanc L, Bond V, Bongiovanni A, Borras FE, Buee L, Buzas EI, Cheng L, Clayton A, Cocucci E, Dela Cruz CS, Desiderio DM, Di Vizio D, Ekstrom K, Falcon-Perez JM, Gardiner C, Giebel B, Greening DW, Gross JC, Gupta D, Hendrix A, Hill AF, Hill MM, Nolte-'t Hoen E, Hwang DW, Inal J, Jagannadham MV, Jayachandran M, Jee YK, Jorgensen M, Kim KP, Kim YK, Kislinger T, Lasser C, Lee DS, Lee H, van Leeuwen J, Lener T, Liu ML, Lotvall J, Marcilla A, Mathivanan S, Moller A, Morhayim J, Mullier F, Nazarenko I, Nieuwland R, Nunes DN, Pang K, Park J, Patel T, Pocsfalvi G, Del Portillo H, Putz U, Ramirez MI, Rodrigues ML, Roh TY, Royo F, Sahoo S, Schiffelers R, Sharma S, Siljander P, Simpson RJ, Soekmadji C, Stahl P, Stensballe A, Stepien E, Tahara H, Trummer A, Valadi H, Vella LJ, Wai SN, Witwer K, Yanez-Mo M, Youn H, Zeidler R, Gho YS.
Bioinformatics. 2014 Nov 10. pii: btu741. [Epub ahead of print]Onco-proteogenomics: cancer proteomics joins forces with genomics.
Alfaro JA, Sinha A, Kislinger T, Boutros PC.
Nat Methods. 2014 Oct 30;11(11):1107-13. doi: 10.1038/nmeth.3138.Proteomic Analysis of Human Fetal Atria and Ventricle.
Lu ZQ, Sinha A, Sharma P, Kislinger T, Gramolini AO.
J Proteome Res. 2014 Oct 31. [Epub ahead of print]Integrated omic analysis of oropharyngeal carcinomas reveals HPV-dependent regulation of the AP-1 pathway.
Sepiashvili L, Waggott D, Hui A, Shi W, Su S, Ignatchenko A, Ignatchenko V, Laureano M, Huang SH, Xu W, Weinreb I, Waldron J, O'Sullivan B, Irish JC, Boutros PC, Liu FF, Kislinger T.
Mol Cell Proteomics. 2014 Sep 30. pii: mcp.M114.041764. [Epub ahead of print]Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands.
Weinreb I, Piscuoglio S, Martelotto LG, Waggott D, Ng CK, Perez-Ordonez B, Harding NJ, Alfaro J, Chu KC, Viale A, Fusco N, da Cruz Paula A, Marchio C, Sakr RA, Lim R, Thompson LD, Chiosea SI, Seethala RR, Skalova A, Stelow EB, Fonseca I, Assaad A, How C, Wang J, de Borja R, Chan-Seng-Yue M, Howlett CJ, Nichols AC, Wen YH, Katabi N, Buchner N, Mullen L, Kislinger T, Wouters BG, Liu FF, Norton L, McPherson JD, Rubin BP, Clarke BA, Weigelt B, Boutros PC, Reis-Filho JS.
Nat Genet. 2014 Nov;46(11):1166-9. doi: 10.1038/ng.3096. Epub 2014 Sep 21.Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.
Shimoda M, Principe S, Jackson HW, Luga V, Fang H, Molyneux SD, Shao YW, Aiken A, Waterhouse PD, Karamboulas C, Hess FM, Ohtsuka T, Okada Y, Ailles L, Ludwig A, Wrana JL, Kislinger T, Khokha R.
Nat Cell Biol. 2014 Sep;16(9):889-901. doi: 10.1038/ncb3021. Epub 2014 Aug 24.Global Proteome Analysis identifies Active Immunoproteasome subunits in Human Platelets.
Klockenbusch C, Walsh GM, Brown LM, Hoffman MD, Ignatchenko V, Kislinger T, Kast J.
Mol Cell Proteomics. 2014 Aug 21. pii: mcp.M113.031757. [Epub ahead of print]Serum proteomic analysis of a pre-symptomatic multiple sclerosis cohort.
Wallin MT1, Oh U, Nyalwidhe J, Semmes J, Kislinger T, Coffman P, Kurtzke JF, Jacobson S.
Eur J Neurol. 2014 Aug 7. doi: 10.1111/ene.12534. [Epub ahead of print]Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function.
Kim HS, Mukhopadhyay R, Rothbart SB, Silva AC, Vanoosthuyse V, Radovani E, Kislinger T, Roguev A, Ryan CJ, Xu J, Jahari H, Hardwick KG, Greenblatt JF, Krogan NJ, Fillingham JS, Strahl BD, Bouhassira EE, Edelmann W, Keogh MC.
Cell Rep. 2014 Mar 13;6(5):892-905. doi: 10.1016/j.celrep.2014.01.029. Epub 2014 Feb 22.The proteomics of prostate cancer exosomes.
Drake RR, Kislinger T.
Expert Rev Proteomics. 2014 Apr;11(2):167-77. doi: 10.1586/14789450.2014.890894. Epub 2014 Feb 25.Proteomic profiles of human lung adeno and squamous cell carcinoma using super-SILAC and label-free quantification approaches.
Zhang W, Wei Y, Ignatchenko V, Li L, Sakashita S, Pham NA, Taylor P, Tsao MS, Kislinger T, Moran MF.
Proteomics. 2014 Mar;14(6):795-803. doi: 10.1002/pmic.201300382.In-depth proteomic analyses of ovarian cancer cell line exosomes reveals differential enrichment of functional categories compared to the NCI 60 proteome.
Sinha A, Ignatchenko V, Ignatchenko A, Mejia-Guerrero S, Kislinger T.
Biochem Biophys Res Commun. 2014 Mar 21;445(4):694-701. doi: 10.1016/j.bbrc.2013.12.070. Epub 2014 Jan 14.
Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state.
Garnier D, Magnus N, Meehan B, Kislinger T, Rak J.
Exp Cell Res. 2013 Oct 15;319(17):2747-57. doi: 10.1016/j.yexcr.2013.08.003. Epub 2013 Aug 13.Novel approaches for the identification of biomarkers of aggressive prostate cancer.
Kim Y, Kislinger T.
Genome Med. 2013 Jun 28;5(6):56. [Epub ahead of print]Analysis of extracellular vesicles: new avenues for signaling biology and biomarker discovery.
Kislinger T.
Proteomics. 2013 May;13(10-11):1551-3. doi: 10.1002/pmic.201370095.In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Principe S, Jones EE, Kim Y, Sinha A, Nyalwidhe JO, Brooks J, Semmes OJ, Troyer DA, Lance RS, Kislinger T, Drake RR.
Proteomics. 2013 Mar 27. doi: 10.1002/pmic.201200561. [Epub ahead of print]Tumor-derived exosomes and microvesicles in head and neck cancer: implications for tumor biology and biomarker discovery.
Principe S, Hui AB, Bruce J, Sinha A, Liu FF, Kislinger T.
Proteomics. 2013 Mar 18. doi: 10.1002/pmic.201200533. [Epub ahead of print]The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover.
Bohgaki M, Hakem A, Halaby MJ, Bohgaki T, Li Q, Bissey PA, Shloush J, Kislinger T, Sanchez O, Sheng Y, Hakem R.
Cell Death Differ. 2013 Mar 1. doi: 10.1038/cdd.2013.7. [Epub ahead of print]
A Combination of H2A.Z and H4 Acetylation Recruits Brd2 to Chromatin during Transcriptional Activation.
Draker R, Ng MK, Sarcinella E, Ignatchenko V, Kislinger T, Cheung P.
PLoS Genet. 2012 Nov;8(11):e1003047. doi: 10.1371/journal.pgen.1003047. Epub 2012 Nov 8.Cancer Cells Induced to Express Mesenchymal Phenotype Release Exosome-like Extracellular Vesicles Carrying Tissue Factor.
Garnier D, Magnus N, Lee TH, Bentley V, Meehan B, Milsom C, Montermini L, Kislinger T, Rak J.
J Biol Chem. 2012 Dec 21;287(52):43565-72. doi: 10.1074/jbc.M112.401760. Epub 2012 Nov 1.Identification of Differentially Expressed Proteins in Direct Expressed Prostatic Secretions of Men with Organ-confined Versus Extracapsular Prostate Cancer.
Kim Y, Ignatchenko V, Yao CQ, Kalatskaya I, Nyalwidhe JO, Lance RS, Gramolini AO, Troyer DA, Stein LD, Boutros PC, Medin JA, Semmes OJ, Drake RR, Kislinger T.
Mol Cell Proteomics. 2012 Dec;11(12):1870-84. doi: 10.1074/mcp.M112.017889. Epub 2012 Sep 17.Potentially Novel Candidate Biomarkers for Head and Neck Squamous Cell Carcinoma Identified Using an Integrated Cell Line-based Discovery Strategy.
Sepiashvili L, Hui A, Ignatchenko V, Shi W, Su S, Xu W, Huang SH, O'Sullivan B, Waldron J, Irish JC, Perez-Ordonez B, Liu FF, Kislinger T.
Mol Cell Proteomics. 2012 Nov;11(11):1404-15. doi: 10.1074/mcp.M112.020933. Epub 2012 Aug 23.Structural determination of the phosphorylation domain of the ryanodine receptor.
Sharma P, Ishiyama N, Nair U, Li W, Dong A, Miyake T, Wilson A, Ryan T, MacLennan DH, Kislinger T, Ikura M, Dhe-Paganon S, Gramolini AO.
FEBS J. 2012 Oct;279(20):3952-64. doi: 10.1111/j.1742-4658.2012.08755.x. Epub 2012 Sep 11.Clinical proteomics: getting to the heart of the matter.
Chugh S, Sharma P, Kislinger T, Gramolini AO.
Circ Cardiovasc Genet. 2012 Jun;5(3):377. doi: 10.1161/CIRCGENETICS.110.957761.Proteomic profiling of the planarian Schmidtea mediterranea and its mucous reveals similarities with human secretions and those predicted for parasitic flatworms.
Bocchinfuso DG, Taylor P, Ross E, Ignatchenko A, Ignatchenko V, Kislinger T, Pearson BJ, Moran MF.
Mol Cell Proteomics. 2012 Sep;11(9):681-91. doi: 10.1074/mcp.M112.019026. Epub 2012 May 31.Cell-Surface Proteomics Identifies Lineage-Specific Markers of Embryo-Derived Stem Cells.
Rugg-Gunn PJ, Cox BJ, Lanner F, Sharma P, Ignatchenko V, McDonald AC, Garner J, Gramolini AO, Rossant J, Kislinger T.
Dev Cell. 2012 Apr 17;22(4):887-901. doi: 10.1016/j.devcel.2012.01.005. Epub 2012 Mar 15.Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells.
Siddiqui NU, Li X, Luo H, Karaiskakis A, Hou H, Kislinger T, Westwood JT, Morris Q, Lipshitz HD.
Genome Biol. 2012 Feb 20;13(2):R11. doi: 10.1186/gb-2012-13-2-r11.Identification of Prostate-Enriched Proteins by In-depth Proteomic Analyses of Expressed Prostatic Secretions in Urine.
Principe S, Kim Y, Fontana S, Ignatchenko V, Nyalwidhe JO, Lance RS, Troyer DA, Alessandro R, Semmes OJ, Kislinger T, Drake RR, Medin JA.
J Proteome Res. 2012 Apr 6;11(4):2386-96. doi: 10.1021/pr2011236. Epub 2012 Feb 29.Glomulin: a permissivity factor for vaccinia virus infection.
Rahbar R, Rogers E, Murooka T, Kislinger T, Fish EN.
J Interferon Cytokine Res. 2012 Mar;32(3):127-37. Epub 2012 Jan 26.The replication-independent histone H3-H4 chaperones HIR, ASF1, and RTT106 co-operate to maintain promoter fidelity.
Silva AC, Xu X, Kim HS, Fillingham J, Kislinger T, Mennella TA, Keogh MC.
J Biol Chem. 2012 Jan 13;287(3):1709-18. Epub 2011 Nov 29.
Translational analysis of mouse and human placental protein and mRNA reveals distinct molecular pathologies in human preeclampsia.
Cox B, Sharma P, Evangelou AI, Whiteley K, Ignatchenko V, Ignatchenko A, Baczyk D, Czikk M, Kingdom J, Rossant J, Gramolini AO, Adamson SL, Kislinger T.
Mol Cell Proteomics. 2011 Dec;10(12):M111.012526. Epub 2011 Oct 10.Choice of bioloical source material supersedes oxidative stress in its influence on DJ-1 in vivo interactions with Hsp90.
Knobbe C, Revett T, Bai Y, Chow V, Jeon AH, Bohm C, Ehsani S, Kislinger T, Mount H, Mak TW, George-Hyslop PS, Schmitt-Ulms G.
J Proteome Res. 2011 Oct 7;10(10):4388-404. Epub 2011 Aug 26.Use of colloidal silica-beads for the isolation of cell-surface proteins for mass spectrometry-based proteomics.
Kim Y, Elschenbroich S, Sharma P, Sepiashvili L, Gramolini AO, Kislinger T.
Methods Mol Biol. 2011;748:227-41.A cost-benefit analysis of multidimensional fractionation of affinity purification-mass spectrometry samples.
Dunham WH, Larsen B, Tate S, Badillo BG, Goudreault M, Tehami Y, Kislinger T, Gingras AC.
Proteomics. 2011 Jul;11(13):2603-12. doi: 10.1002/pmic.201000571. Epub 2011 Jun 1.In-depth proteomics of ovarian cancer ascites: combining shotgun proteomics and selected reaction monitoring mass spectrometry.
Elschenbroich S, Ignatchenko V, Clarke B, Kalloger SE, Boutros PC, Gramolini AO, Shaw P, Jurisica I, Kislinger T.
J Proteome Res. 2011 May 6;10(5):2286-99. Epub 2011 Apr 14.Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP).
Ryan T, Sharma P, Ignatchenko A, MacLennan DH, Kislinger T, Gramolini AO.
J Biol Chem. 2011 May 13;286(19):17060-8. Epub 2011 Mar 14.Identification of an FHL1 protein complex containing ACTN1, ACTN4, and PDLIM1 using affinity purifications and MS-based protein-protein interaction analysis.
Sharma P, Shathasivam T, Ignatchenko V, Kislinger T, Gramolini AO.
Mol Biosyst. 2011 Apr;7(4):1185-96. Epub 2011 Jan 18.Targeted proteomics by selected reaction monitoring mass spectrometry: applications to systems biology and biomarker discovery.
Elschenbroich S, Kislinger T.
Mol Biosyst. 2011 Feb 1;7(2):292-303. Epub 2010 Oct 25.
Constitutively active calcineurin induces cardiac endoplasmic reticulum stress and protects against apoptosis that is mediated by alpha-crystallin-B.
Bousette N, Chugh S, Fong V, Isserlin R, Kim KH, Volchuk A, Backx PH, Liu P, Kislinger T, MacLennan DH, Emili A, Gramolini AO.
Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18481-6. Epub 2010 Oct 11 .Genes, proteins and complexes: The multifaceted nature of FHL family proteins in diverse tissues.
Shathasivam T, Kislinger T, Gramolini AO.
J Cell Mol Med. 2010 Dec;14(12):2702-20. doi: 10.1111/j.1582-4934.2010.01176.x. Review.Primary Tumor Xenografts of Human Lung Adeno and Squamous Cell Carcinoma Express Distinct Proteomic Signatures.
Wei Y, Tong J, Taylor P, Strumpf D, Ignatchenko V, Pham NA, Yanagawa N, Liu G, Jurisica I, Shepherd FA, Tsao MS, Kislinger T, Moran MF.
J Proteome Res. 2011 Jan 7;10(1):161-74. Epub 2010 Sep 24.Systems-level analysis of neuroblastoma tumor-initiating cells implicates AURKB as a novel drug target for neuroblastoma.
Morozova O, Vojvodic M, Grinshtein N, Hansford LM, Blakely KM, Maslova A, Hirst M, Cezard T, Morin RD, Moore R, Smith KM, Miller F, Taylor P, Thiessen N, Varhol R, Zhao Y, Jones SJ, Moffat J, Kislinger T, Moran MF, Kaplan D, Marra MA.
Clin Cancer Res. 2010 Sep 15;16(18):4572-82. Epub 2010 Jul 22.Endoplasmic reticulum protein targeting of phospholamban: a common role for an N-terminal di-arginine motif in ER retention?
Sharma P, Ignatchenko V, Grace K, Ursprung C, Kislinger T, Gramolini AO.
PLoS One. 2010 Jul 9;5(7):e11496.MicroRNA Networks in Mouse Lung Organogenesis.
Dong J, Jiang G, Asmann YW, Tomaszek S, Jen J, Kislinger T, Wigle DA.
PLoS One. 2010 May 26;5(5):e10854.Proteome analysis of mouse model systems: A tool to model human disease and for the investigation of tissue-specific biology.
Kislinger T, Gramolini AO.
J Proteomics. 2010 Oct 10;73(11):2205-18. Epub 2010 May 15.A live zebrafish-based screening system for human nuclear receptor ligand and cofactor discovery.
Tiefenbach J, Moll PR, Nelson MR, Hu C, Baev L, Kislinger T, Krause HM.
PLoS One. 2010 Mar 22;5(3):e9797.In-depth proteomic analyses of direct expressed prostatic secretions.
Drake RR, Elschenbroich S, Lopez-Perez O, Kim Y, Ignatchenko V, Ignatchenko A, Nyalwidhe JO, Basu G, Wilkins CE, Gjurich B, Lance RS, Semmes OJ, Medin JA, Kislinger T.
J Proteome Res. 2010 May 7;9(5):2109-16.Isolation of cell surface proteins for mass spectrometry-based proteomics.
Elschenbroich S, Kim Y, Medin JA, Kislinger T.
Expert Rev Proteomics. 2010 Feb;7(1):141-54.
Method for the affinity purification of covalently linked peptides following cyanogen bromide cleavage of proteins.
Shi T, Weerasekera R, Yan C, Reginold W, Ball H, Kislinger T, Schmitt-Ulms G.
Anal Chem. 2009 Dec 15;81(24):9885-95.An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe.
Kim HS, Vanoosthuyse V, Fillingham J, Roguev A, Watt S, Kislinger T, Treyer A, Carpenter LR, Bennett CS, Emili A, Greenblatt JF, Hardwick KG, Krogan NJ, Bahler J, Keogh MC.
Nat Struct Mol Biol. 2009 Dec;16(12):1286-93. Epub 2009 Nov 15.Peptide separations by on-line MudPIT compared to isoelectric focusing in an off-gel format: Application to a membrane-enriched fraction from C2C12 mouse skeletal muscle cells.
Elschenbroich S, Ignatchenko V, Sharma P, Schmitt-Ulms G, Gramolini A, Kislinger T.
J Proteome Res. 2009 Oct;8(10):4860-9.Large-scale characterization and analysis of the murine cardiac proteome.
Bousette N, Kislinger T, Fong V, Isserlin R, Hewel JA, Emil A, Gramolini AO.
J Proteome Res. 2009 Apr;8(4):1887-901.Automated 2D peptide separation on a 1D nano-LC-MS system.
Taylor P, Nielsen PA, Trelle MB, Horning OB, Andersen MB, Vorm O, Moran MF, Kislinger T.
J Proteome Res. 2009 Mar;8(3):1610-6.Comparative systems biology of human and mouse as a tool to guide the modeling of human placental pathology.
Cox B, Kotlyar M, Evangelou AI, Ignatchenko V, Ignatchenko A, Whiteley K, Jurisica I, Adamson SL, Rossant J, Kislinger T.
Mol Syst Biol. 2009;5:279. Epub 2009 Jun 16.Lung cancer: developmental networks gone awry?
Dong J, Kislinger T, Jurisica I, Wigle DA.
Cancer Biol Ther. 2009 Feb;8(4):312-8. Epub 2009 Feb 1.Quantitative peptide and protein profiling by mass spectrometry.
Schmidt A, Bisle B, Kislinger T.
Methods Mol Biol. 2009;492:21-38.
Advances in ovarian cancer proteomics: the quest for biomarkers and improved therapeutic interventions.
Jurisicova A, Jurisica I, Kislinger T.
Expert Rev Proteomics. 2008 Aug;5(4):551-60.Identification of pathways associated with invasive behavior by ovarian cancer cells using multidimensional protein identification technology (MudPIT).
Sodek KL, Evangelou AI, Ignatchenko A, Agochiya M, Brown TJ, Ringuette MJ, Jurisica I, Kislinger T.
Mol Biosyst. 2008 Jul;4(7):762-73. Epub 2008 Apr 17.Mass spectrometry-based proteomics: a useful tool for biomarker discovery?
Gramolini AO, Peterman SM, Kislinger T.
Clin Pharmacol Ther. 2008 May;83(5):758-60. Epub 2008 Mar 19.The Glc7 phosphatase subunit of the cleavage and polyadenylation factor is essential for transcription termination on snoRNA genes.
Nedea E, Nalbant D, Xia D, Theoharis NT, Suter B, Richardson CJ, Tatchell K, Kislinger T, Greenblatt JF, Nagy PL.
Mol Cell. 2008 Mar 14;29(5):577-87.Comparative proteomics profiling of a phospholamban mutant mouse model of dilated cardiomyopathy reveals progressive intracellular stress responses.
Gramolini AO, Kislinger T, Alikhani-Koopaei R, Fong V, Thompson NJ, Isserlin R, Sharma P, Oudit GY, Trivieri MG, Fagan A, Kannan A, Higgins D, Huedig H, Hess G, Arab S, Seidman JG, Seidman CE, Frey B, Perry M, Backx PH, Liu PP, Maclennan DH, Emili A.
Mol Cell Proteomics. 2008 Mar;7(3):519-33. Epub 2007 Nov 30.A Proteome Resource of Ovarian Cancer Ascites: Integrated Proteomic and Bioinformatic Analyses To Identify Putative Biomarkers.
Gortzak-Uzan L, Ignatchenko A, Evangelou AI, Agochiya M, Brown KA, St Onge P, Kireeva I, Schmitt-Ulms G, Brown TJ, Murphy J, Rosen B, Shaw P, Jurisica I, Kislinger T.
J Proteome Res. 2008 Jan;7(1):339-51. Epub 2007 Dec 13.
Impaired tRNA nuclear export links DNA damage and cell-cycle checkpoint.
Ghavidel A, Kislinger T, Pogoutse O, Sopko R, Jurisica I, & Emili A.
Cell 2007, 131: 915-926.Interactome and interface protocol (2IP): a novel strategy for high sensitivity topology mapping of protein complexes.
Weerasekera R, She Y, Markham KA, Bai Y, Opalka N, Orlicky S, Sicheri F, Kislinger T, & Schmitt-Ulms G.
Proteomics 2007; 21: 3835-3852Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes.
Cox B, Kislinger T, Wigle DA, Brown K, Jurisica I, Emili A, & Rossant J.
Mol Syst Biol 2007; 3:109Cancer informatics in the post genomic era. Toward information-based medicine.
Jurisica I, Wigle DA, Wong B, Tsao M, Liu J, Johnston M, & Kislinger T.
Cancer Treat Res 2007, 1-178Analyzing the cardiac muscle proteome by liquid chromatography-mass spectrometry-based expression proteomics.
Gramolini AO, Kislinger T, Liu P, MacLennan DH, & Emili A.
Methods Mol Biol 2007; 357, 15-31The application of shot-gun expression proteomics and computational data mining strategies in medical research and biomarker discovery.
Evangelou A, Gortzak-Uzan L, Jurisica I, & Kislinger T.
Anti-Infective Agents in Medicinal Chemistry 2007; 6: 89-105
Global Survey of Organ and Organelle Protein Expression in Mouse: Combined Proteomic and Transcriptomic Profiling.
Kislinger T, Cox B, Kannan A, Chung C, Hu P, Ignatchenko A, Scott SS, Gramolini AO, Morris Q, Hallett MT, Rossant J, Hughes TR, Frey B, & Emili A.
Cell 2006, 125: 173-186Sarcolipin transgenic overexpression in phospholamban null cardiac muscle impairs function.
Gramolini AO, Trivieri MG, Oudit G, Kislinger T, Li W, Patel M, Kranias EG, Backx PH, & MacLennan DH.
PNAS USA 2006; 103: 2446-2451Cardiovascular proteomics: Tools to develop novel biomarkers and potential applications.
Arab S, Gramolini AO, Ping P, Kislinger T, Stanley B, van Eyk J, MacLennan DH, Emili A, & Liu PP.
J Am Coll Cardiol 2006; 48: 1733-1741Proteomics and Bioinformatics in Biomedical Research.
Kislinger T, & Jurisica J.
Cancer Genomics & Proteomics 2006; 3: 11-28
Global protein shotgun expression profiling of Proliferating MCF-7 breast cancer cell.
Sandhu C, Conner M, Kislinger T, Slingerland J, & Emili A.
J Proteome Research 2005; 4:674-689RAGE limits regeneration after massive liver injury by coordinated suppression of TNF-alpha and NF-kappaB.
Cataldegirmen G, Zeng S, Feirt N, Ippagunta N, Dun H, Qu W, Lu Y, Rong LL, Hofmann MA, Kislinger T, Pachydaki SI, Jenkins DG, Weinberg A, Lefkowitch J, Rogiers X, Yan SF, Schmidt AM, & Emond JC.
J Exp Med 2005, 201: 473-484Proteome dynamics during C2C12 myoblast differentiation.
Kislinger T, Gramolini AO, Pan Y, Rahman K, MacLennan DH, & Emili A.
Mol Cell Proteomics 2005; 7: 887-901Knowledge Discovery in High-Throughput Biological Domains.
Kislinger T & Emili A.
Chapman & Hall/CRC Mathematical Biology and Medicine Series. Igor Jurisica and Dennis Wigle (Eds). 2005. Chapter 3 - Current status and future prospectives of mass spectrometry pp 55-87Analysis of Protein Glycation Products by MALDI-TOF/MS.
Kislinger T, Humeny A, Peich CC, Becker CM, & Pischetsrieder M.
Ann N Y Acad Sci 2005; 1043: 249-259Integrating Gene and Protein Expression Data: Pattern Analysis and Profile Mining.
Cox B, Kislinger T, & Emili A.
Methods 2005; 35: 303-314Multidimensional protein identification technology (MudPIT): Current status and future prospective.
Kislinger T, & Emili A.
Expert Rev Proteomics 2005; 1:27-39Multidimensional protein identification technology (MudPIT): Technical overview of a profiling method optimized for the comprehensive proteomic investigation of normal and diseased heart tissue.
Kislinger T, Gramolini AO, MacLennan DH, & Emili A.
J Am Soc Mass Spectrom 2005; 16: 1207-1220
Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions.
Coppinger J, Cagney G, Toomey S, Kislinger T, Belton O, McRedmond J, Emili A, Fitzgerald D, Maguire P, & Cahill D.
Blood 2004; 103: 2096-2104Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics.
Pan Y, Kislinger T, Gramolini AO, Zvaritch E, Kranias EG, MacLennan DH, & Emili A.
PNAS USA 2004; 101: 2241-2246Sarcolipin retention in the endoplasmic reticulum is dependent on its C-terminal amino acid motif, RSYQY, and interaction with GRP78/Bip and GRP94 in the absence of stochiometric amounts of sarco(endo)plasmic Ca2+ ATPase.
Gramolini AO, Kislinger T, Li W, Asahi M, Emili A, & MacLennan DH.
PNAS USA 2004; 101: 16807-16812PRISM - A new strategy to analyze the mammalian proteome.
Kislinger T, Cox B, & Emili A.
TARGETS – Drug Discovery Today Publications, Elsevier 2004; 3: S37-42Kislinger T, Humeny A, & Pischetsrieder M.
Detection of protein glycation products by matrix-assisted laser desorption ionization time-of-flight mass spectrometry.
Curr Med Chem 2004; 11: 2185-2193
Relative quantitation of N(epsilon)-(carboxymethyl)lysine, Imidazolone A, and the Amadori product in glycated lysozyme by MALDI-TOF mass spectrometry.
Kislinger T, Humeny A, Peich C, Zhang X, Becker CM, & Pischetsrieder M.
J Agric Food Chem 2003; 51: 51-57PRISM: A generic large-scale proteomics investigation strategy for mammals.
Kislinger T, Rahman K, Radulovic D, Cox B, Rossant J, & Emili A.
Mol Cell Proteomics 2003; 2:96-106RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy.
Wendt TM, Nozomu T, Jiancheng G, Kislinger T, Qu W, Lu Y, Bucciarelli LG, Rong LL, Moser B, Markowitz GS, Stein G, Bierhaus A, Liliensiek B, Arnold B, Nawroth PP, Stern DM, D'Agati VD, & Schmidt AM.
Am J Pathol 2003; 162: 1123-1137Going global: protein expression profiling using shotgun mass spectrometry.
Kislinger T & Emili A.
Curr Opin Mol Ther 2003; 5: 285-293
Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses.
Basta G, Lazzerini G, Massaro M, Simoncini T, Tanganelli P, Fu C, Kislinger T, Stern DM, Schmidt AM, & De Caterina R.
Circulation 2002; 105: 816-822Qualitative determination of specific protein glycation products by matrix-assisted laser desorption/ionization mass spectrometry Peptide mapping.
Humeny A, Kislinger T, Becker CM, & Pischetsrieder M.
J Agric Food Chem 2002; 50: 2153-2160Qualitative determination of early Maillard-products by MALDI-TOF mass spectrometry peptide mapping.
Kislinger T, Humeny A, Seeber S, Becker CM, & Pischetsrieder M.
Eur Food Res Technol 2002; 215: 65-71RAGE blockade stabilizes established atherosclerosis in diabetic apolipoprotein E null mice.
Bucciarelli LG, Wendt T, Qu W, Lu Y, Lalla E, Rong LL, Goova MT, Moser B, Kislinger T, Lee DC, Kashyap Y, Stern DM & Schmidt AM.
Circulation 2002; 106: 2827-2835Research in Legal Medicine Vol 27: AGING – Morphological, Biochemical, Molecular and Social Aspects. Manfred Oehmichen, Stefanie Ritz-Timme, Christoph Meissner (Eds). Schmidt-Romhild 2002. Chapter: Protein Biochemistry pp 235-247
Kislinger T, Schneider M, & Pischetsrieder M.
Receptor for advanced glycation end products mediates inflammation and enhanced expression of tissue factor in vasculature of diabetic apolipoprotein E-null mice.
Kislinger T, Tanji N, Wendt T, Qu W, Lu Y, Ferran LJ Jr, Taguchi A, Olson K, Bucciarelli L, Goova M, Hofmann MA, Cataldegirmen G, D'Agati V, Pischetsrieder M, Stern DM, & Schmidt AM.
Arterioscler Thromb Vasc Biol 2001; 21: 905-910Blockade of receptor for advanced glycation end-products restores effective wound healing in diabetic mice.
Goova MT, Li J, Kislinger T, Qu W, Lu Y, Bucciarelli LG, Nowygrod S, Wolf BM, Caliste X, Yan SF, Stern DM, & Schmidt AM.
Am J Pathol 2001; 159: 513-525
Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice.
Lalla E, Lamster IB, Feit M, Huang L, Spessot A, Qu W, Kislinger T, Lu Y, Stern DM, & Schmidt AM.
J Clin Invest 2000; 105: 1117-1124Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases.
Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W, Tanji N, Lu Y, Lalla E, Fu C, Hofmann MA, Kislinger T, Ingram M, Lu A, Tanaka H, Hori O, Ogawa S, Stern DM, & Schmidt AM.
Nature 2000; 405: 354-360Expression of advanced glycation end products and their cellular receptor RAGE in diabetic nephropathy and nondiabetic renal disease.
Tanji N, Markowitz GS, Fu C, Kislinger T, Taguchi A, Pischetsrieder M, Stern D, Schmidt AM, & D'Agati VD.
J Am Soc Nephrol 2000; 11: 1656-1666Determination of N-epsilon-carboxymethyllysine in heated milk products by immunochemical methods.
Tauer A, Hasenkopf K, Kislinger T, Frey I, & Pischetsrieder M.
Eur Food Res Technol 1999; 209: 72-76N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression.
Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Du Yan S, Hofmann M, Yan SF, Pischetsrieder M, Stern D, & Schmidt AM.
J Biol Chem 1999 ; 274: 31740-31749Barbiturate induced benzophenanthridine alkaloid formation proceeds by gene transcript accumulation in the California poppy.
Haider G, Kislinger T, & Kutchan TM.
Biochem Biophys Res Commun 1997; 241: 606-610